Abstract: Tests of Lorentz and CPT invariance have been central in the developing of our understanding of Nature. While there is a vast amount of results from "classical tests" and studies of stable particles, not much is known about the strong interaction sector, which is clouded in non-perturbative effects. I discuss the quark sector of the Standard Model Extension, a framework which can be used to describe generic Lorentz and CPT violation, and show how high-energy collider processes can be used to access directly these effects. I conclude presenting constraints obtained from a recent analysis of the entire Deep Inelastic Scattering dataset collected by the Zeus detector.